
The Kansas City Chiefs now look all but certain to be without their all-time leading rusher in Sunday’s season opener against the San Diego Chargers.
Chiefs head coach Andy Reid said on Friday that All-Pro running back Jamaal Charles is doubtful for Week 1 and is “probably not going to play,” per Terez A. Paylor of the Kansas City Star.
Jamaal Charles is doubtful for Sunday's game, Andy Reid said. "He's probably not going to play," he said.
— Terez A. Paylor (@TerezPaylor) September 9, 2016

This is consistent with what the Chiefs have been saying in recent days about the availability of the 29-year-old Charles, who is working his way back from his second ACL tear in four years.
Charles rushed for 364 yards and four touchdowns last season before going down in Week 5. Now past his prime and coming off a second major knee injury, it will be tough for the four-time Pro Bowler to reclaim his stranglehold on the Kansas City rushing game, especially with Charcandrick West and Spencer Ware looking poised to fight for bigger roles and Knile Davis ready to pick up the scraps.
H/T Rotoworld