The release of the NFL schedule has also allowed for the oddsmakers to offer their initial thoughts on the slate of games, and one team will not be getting much faith from Las Vegas this season.
Initial odds have the Arizona Cardinals as underdogs in all 17 games on their schedule. Worse yet, each of their first 11 opponents is favored by more than a touchdown.
The #Cardinals are underdogs in every game this season, and they are TD-or-more underdogs in each of their first 11 games:
— Ari Meirov (@MySportsUpdate) May 15, 2026
Wk 1: @ Chargers (+11.5)
Wk 2: Seahawks (+10)
Wk 3: @ 49ers (+11.5)
Wk 4: @ Giants (+7)
Wk 5: Lions (+8.5)
Wk 6: @ Rams (+13.5)
Wk 7: Broncos (+7.5)
Wk 8: @… pic.twitter.com/bPplNYz1ol
There are a number of reasons people are so low on the Cardinals. Their roster lacks talent, and they play in an NFC West that boasts three potential playoff teams. They are even at odds with their starting quarterback over contractual matters, and only have Gardner Minshew and rookie Carson Beck in place as backup.
The Cardinals went just 3-14 last season. Two of those three wins came in their first two games of the season, meaning they lost 14 of 15 games to end their campaign.
Arizona is also the heavy favorite to finish with the fewest wins of any team in the league. They could be in for a very long season.
The Arizona Cardinals are the only NFL team priced as an underdog in all 17 games this season.
— Julian Edlow (@julianedlow) May 15, 2026
AZ is a double digit dog in each of its first 3 games, and nearly half of its total games (8).
AZ is an underdog of a touchdown or more 13 times, including its first 11 games.
The… pic.twitter.com/yoGdR0VHxU














