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FootballArizona Cardinals

Initial odds have 1 NFL team favored to lose every game

May 15, 2026 by Grey Papke • Comments
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The NFL logo on a helmet
Sep 29, 2016; London, United Kingdom; General view of NFL shield logo helmet and British and United States flags on Regent Street pror to the NFL International Series game between the Indianapolis Colts and the Jacksonville Jaguars. Mandatory Credit: Kirby Lee-USA TODAY Sports

The release of the NFL schedule has also allowed for the oddsmakers to offer their initial thoughts on the slate of games, and one team will not be getting much faith from Las Vegas this season.

Initial odds have the Arizona Cardinals as underdogs in all 17 games on their schedule. Worse yet, each of their first 11 opponents is favored by more than a touchdown.

The #Cardinals are underdogs in every game this season, and they are TD-or-more underdogs in each of their first 11 games:

Wk 1: @ Chargers (+11.5)
Wk 2: Seahawks (+10)
Wk 3: @ 49ers (+11.5)
Wk 4: @ Giants (+7)
Wk 5: Lions (+8.5)
Wk 6: @ Rams (+13.5)
Wk 7: Broncos (+7.5)
Wk 8: @… pic.twitter.com/bPplNYz1ol

— Ari Meirov (@MySportsUpdate) May 15, 2026

There are a number of reasons people are so low on the Cardinals. Their roster lacks talent, and they play in an NFC West that boasts three potential playoff teams. They are even at odds with their starting quarterback over contractual matters, and only have Gardner Minshew and rookie Carson Beck in place as backup.

The Cardinals went just 3-14 last season. Two of those three wins came in their first two games of the season, meaning they lost 14 of 15 games to end their campaign.

Arizona is also the heavy favorite to finish with the fewest wins of any team in the league. They could be in for a very long season.

The Arizona Cardinals are the only NFL team priced as an underdog in all 17 games this season.

AZ is a double digit dog in each of its first 3 games, and nearly half of its total games (8).

AZ is an underdog of a touchdown or more 13 times, including its first 11 games.

The… pic.twitter.com/yoGdR0VHxU

— Julian Edlow (@julianedlow) May 15, 2026
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